Provider: Silverchair Database: Oxford University Press Content: text/plain; charset="UTF-8" TY - JOUR AU - Moretti, Sébastien AU - Niknejad, Anne AU - Pagni, Marco AU - Mehl, Florence T1 - MetaNetX: a bridge between metabolic resources for enhanced curation and multi-omics data harmonization PY - 2026 Y1 - 2026/01/06 DO - 10.1093/nar/gkaf1286 JO - Nucleic Acids Research JA - Nucleic Acids Res VL - 54 IS - D1 SP - D617 EP - D622 SN - 1362-4962 AB - MetaNetX (https://www.metanetx.org/) is a comprehensive resource for the reconciliation and integration of metabolic information across diverse biochemical databases. The 2025 update significantly enhances chemical and reaction coverage, incorporating new data and refining chemical structure computation and normalization. These improvements support more accurate reconciliation across sources and enable robust multi-omics integration through standardized identifiers (InChI, SMILES) and curated R-group definitions. The Resource Description Format (RDF) graph has been expanded to capture reconciliation history, and the SPARQL endpoint now includes enriched documentation and example queries, facilitating programmatic access and integration with AI tools. Together, these developments reinforce MetaNetX as a high-quality, open-access platform for systems biology, metabolic modeling, and multi-omics data analysis. Y2 - 1/22/2026 UR - https://doi.org/10.1093/nar/gkaf1286 ER -